p38MAPK信号转导通路与组织损伤

丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)是广泛表达的丝氨酸/酪氨酸激酶,在哺乳动物细胞多种信号转导通路中起重要作用。MAPK有4个主要亚族:ERK、p38MAPK、JNK和ERK5。p38信号通路是MAPK通路的一重要分支,它在炎症、细胞应激、凋亡、细胞周期和生长等多种生理和病理过程中起重要作用。本文就p38MAPK的分型、分布、信号通路的组成及其在法医损伤学领域中的应用现状做一综述,旨在进一步对组织损伤程度和伤后时间推断的法医病理学研究提供参考资料。

P38MAPK signal transduction pathway and tissue lesion

Mitogen-activated protein kinase,a kind of serine and tyrosine kinase,is widely expressed in mammalian cells,which plays an important role in a variety of signal transduction pathways.There are four subtribes in MAPK including ERK,JNK,p38MAPK and ERK5,among which p38MAPK signal transduction pathway plays pivotal roles in various physiological and pathological events,such as inflammation,cell stress,apoptosis,cell cycle and growth.The isomers and distribution of p38MAPK,and cytokines associated with p38MAPK pathway and their roles in tissue damages are reviewed in this article,which may provide understanding for wound severity and wound age estimation in the research field of forensic pathology.