| 溺死大鼠肺组织水通道蛋白1的表达 |
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| 作者姓名： | Hu HZ Yang C Zhi-gang L |
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| 作者单位： | 1. 四川大学基础医学与法医学院法医病理教研室,四川,成都,610041
2. 成都市公安局刑事科学技术研究所,四川,成都,610041 |
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| 摘 要： | 目的检测生前溺死与死后抛尸的肺组织水通道蛋白的表达。方法取2种死亡方式条件下大鼠肺组织,用免疫组织化学方法检测肺组织中水通道蛋白1表达的分布特征。结果两种死亡条件下肺泡间质和支气管周围的毛细血管内皮及肺泡上皮均有AQP1的阳性表达,但积分光密度值(intergratedopticaldensity,IOD)值有显著性差别。结论AQP1在大鼠两种溺死条件下表达差别有统计学意义。
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| 关 键 词： | AQP1 溺死 免疫组化 图像分析系统 |
| 文章编号： | 1004-5619(2004)01-0013-02 |
| 修稿时间： | 2003年6月16日 |
Expression of water channel protein 1 in the lung of the drown rat |
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| Hu HZ,Yang C,Zhi-gang L.Expression of water channel protein 1 in the lung of the drown rat[J].Journal of Forensic Medicine,2004,20(1):13-14,F003. |
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| Authors: | Hu Hua-zi Yang Chen Zhi-gang Liao |
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| Institution: | West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. |
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| Abstract: | Objective To determine the expression of water channel1protein in the lung of drown rat and that of after death thrown into the water.Methods Immunohistochemical method was used and the computer image analysis was conducted to detect the distribution of AQP1.Results The positive expres-sion of AQP1was seen in the capillary endotheliocyte of the interstitial and around bronchi and in the alveolar endothelial cells.The value of intergrated optical density was statistical significant.Conclusion It suggests that AQP1is one of sensitive signs to distinguish ante-mortem and postmortem immersion. |
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| Keywords: | aquaporin drown immunohistochemistry image analysis system |
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