| 内标监控反相高效液相色谱法测定生物材料中的立克命 |
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| 引用本文： | 颜健,颜有仪,郭平,李章万,江焘. 内标监控反相高效液相色谱法测定生物材料中的立克命[J]. 中国法医学杂志, 1990, 0(1) |
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| 作者姓名： | 颜健 颜有仪 郭平 李章万 江焘 |
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| 作者单位： | 华西医科大学，华西医科大学，华西医科大学，华西医科大学，华西医科大学 |
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| 摘 要： | 本文经实验研究,建立了以1,1′-联-(2-萘酚)作为内标监控检测生物材料中立克命的反相HPLC 方法。经实验证明空白兔肝中添加回收率达90%,同一染毒兔肝多次测定结果表明有较满意的重现性。生物材料中的内源性杂质不干扰测定。本法可用于分析毒理学的研究,也可用于立克命中毒案件的检验。
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| 关 键 词： | 立克命(杀鼠迷) 高效液相色谱分析 |
DETERMINATION OF THE COUMATETRALYL IN BIOLOGICAL MATERIALS BY RPHPLC METHOD USING INTERNAL STANDARD |
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| Yan Jian Yan Youyi Guo Ping Li Zhangwan Jiag Tao. DETERMINATION OF THE COUMATETRALYL IN BIOLOGICAL MATERIALS BY RPHPLC METHOD USING INTERNAL STANDARD[J]. Chinese Journal of Forensic Medicine, 1990, 0(1) |
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| Authors: | Yan Jian Yan Youyi Guo Ping Li Zhangwan Jiag Tao |
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| Affiliation: | Yan Jian Yan Youyi Guo Ping Li Zhangwan Jiag Tao Department of toxicological analysis West china University of Medical scinces,chengdu |
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| Abstract: | A simple,reliable RPHPLC method on ODS column with UV detector for deter-mination of the anticoagulant rodenticide coumatetralyl in animal tissue was developed.1,1′-Bi-(2-Naphthol)was used as an internal standard to check the process ofexperiments.The mean recoveries from the spiked rabbit liver were around 90% atthe levels of 0.4-16mg/kg.The coeffecint of variation of 5 determination was 3.2%.The results showed that this method has a satisfactory reproducibility.The methodis practical for examining poisons in poisoning cases. |
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| Keywords: | Coumatetralyl RP HPLC method |
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