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| 甲基苯丙胺和乙醇在染毒大鼠体内联用的实验研究 | |
| 引用本文： | 梁曼,刘艳,任亮,李学博,张海东,刘良. 甲基苯丙胺和乙醇在染毒大鼠体内联用的实验研究[J]. 中国法医学杂志, 2011, 26(6): 447-450 |
| 作者姓名： | 梁曼 刘艳 任亮 李学博 张海东 刘良 |
| 作者单位： | 1. 华中科技大学同济医学院法医系,湖北武汉,430030 2. 重庆医科大学,重庆,400016 3. 华中科技大学同济医学院法医系,湖北武汉430030;中国政法大学证据科学教育部重点实验室,北京100040 |
| 基金项目： | 国家自然科学基金资助项目(81072505); 华中科技大学自主创新研究基金(2011QN198) |
| 摘 要： | 目的研究甲基苯丙胺（MA）和乙醇联合应用在急性、亚急性染毒大鼠体内的情况。方法以MA1.0 mg/kg剂量对慢性自由饮酒大鼠多次腹腔注射,分别建立急性、亚急性染毒大鼠模型;处死后即时检测血中乙醇浓度、体液和组织样品中MA的浓度。结果多次注入MA药后,亚急性中毒大鼠体内的MA浓度高于急性中毒大鼠;急性和亚急性联合中毒大鼠体内MA浓度均高于急性和亚急性单一药物组。结论无论是否联用乙醇,14d内增加注射次数会在大鼠体内产生不同程度的MA残留;与乙醇联用可加速MA在大鼠体内的吸收,其药物浓度的升高程度随生物样品不同存在差异。 |
| 关 键 词： | 法医毒理学 甲基苯丙胺 乙醇 中毒 气相色谱法 气相色谱-质谱联用 |
Distribution of methamphetamine and ethanol in acute and sub-acute poisoned rats |
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| LIANG Man,LIU Yan,REN Liang,LI Xuebo,ZHANG Haidong,LIU Liang. Distribution of methamphetamine and ethanol in acute and sub-acute poisoned rats[J]. Chinese Journal of Forensic Medicine, 2011, 26(6): 447-450 | |
| Authors: | LIANG Man LIU Yan REN Liang LI Xuebo ZHANG Haidong LIU Liang |
| Affiliation: | (LIANG Man1,LIU Yan1,REN Liang1,LI Xuebo2,ZHANG Haidong3,LIU Liang1,3/1.Faculty of Forensic Medicine,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China,2.Chongqing Medical University,Chongqing 400016,3.Institute of Evidence Science of China Political and Law University,Beijing 100040,China) |
| Abstract: | Objective To investigate distribution of methamphetamine(MA) and ethanol in acute and sub-acute poisoned rats.Methods After multi-intraperitoneal injections of MA(1.0 mg/kg) to chronic self-drinking rats,models of acute and sub-acute combined-use poisoned rats were set up.MA samples in organs and body fluid and ethanol in peripheral blood were determined immediately after the rats died.Results The concentrations of MA in sub-acute poisoned rats were higher than the acute poisoned ones;and the concentrations... |
| Keywords: | forensic toxicology methamphetamine ethanol poisoning gas chromatography(GC) gas chromatography-mass spectrometry(GC/MS) |
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