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| 原发性脑干损伤神经元凋亡及caspase3的表达 | |
| 引用本文： | 张能培,罗斌,姚青松,吕国丽,赵勇,棠一璇. 原发性脑干损伤神经元凋亡及caspase3的表达[J]. 中国法医学杂志, 2011, 26(5): 377-379,434 |
| 作者姓名： | 张能培 罗斌 姚青松 吕国丽 赵勇 棠一璇 |
| 作者单位： | 1. 东莞市公安局刑警支队,广东东莞,523008 2. 中山大学中山医学院法医病理教研室,广东广州,510080 3. 广州市刑事科学技术研究所,广东广州,510030 |
| 摘 要： | 目的观察原发性脑干损伤（PBSI）致死者脑干神经元凋亡及caspase3的表达情况,探讨其法医学意义。方法选择法医学检案中30例确定为原发性脑干损伤致死者脑干,按伤后不同存活时间（t≤5min、5min〈t≤15min、15min〈t≤1h、1h〈t≤24h）分为4组,以5例非脑干损伤死亡者脑干为对照组;分别运用常规HE、免疫组化和TUNEL染色检测中脑、桥脑及延脑重要核团内神经元凋亡及caspase3的表达情况。结果原发性脑干损伤后15min～24h出现明显神经元细胞凋亡（23.2%～35.9%）和caspase3阳性表达（28%～54%）,并呈现随损伤时间进行性增加的趋势,与对照组有显著性差异（P〈0.01）。结论原发性脑干损伤早期即出现神经元凋亡及caspase3表达增加,并随损伤时间的延长呈进行性增加,可据此辅助诊断原发性脑干损伤死亡。 |
| 关 键 词： | 法医病理学 原发性脑干损伤 caspase3 凋亡 |
A study for neuron apoptosis and expression of caspase3 in the human primary brainstem injury |
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| ZHANG Nengpei,LUO Bin,YAO Qingsong,LV Guoli,ZHAO Yong,SONG Yixuan. A study for neuron apoptosis and expression of caspase3 in the human primary brainstem injury[J]. Chinese Journal of Forensic Medicine, 2011, 26(5): 377-379,434 | |
| Authors: | ZHANG Nengpei LUO Bin YAO Qingsong LV Guoli ZHAO Yong SONG Yixuan |
| Affiliation: | (ZHANG Nengpei1,LUO Bin2,YAO Qingsong3,LV Guoli3,ZHAO Yong1,SONG Yixuan2/ 1.Detachment of Criminal Police,Dongguan Public Security Bureau,Guangdong Dongguan 523008,China,2.Department of Forensic Pathology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,3.Guangzhou Institute of Criminal Sciences and Techology,Guangzhou 510030,China) |
| Abstract: | Objective To study the neuron apoptosis and expression of caspase3 in the brainstem of the victims died from primary brainstem injury.Methods Neuron apoptosis and expression of caspase3 in dorsal nucleus of vagus nerve and reticular formation were evaluated quantitatively at different posttraumatic time points(t≤5min;5min |
| Keywords: | forensic pathology primary brainstem injury caspase3 apoptosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |