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| 创伤性脑损伤动物模型研究进展 | |
| 引用本文： | Li SX,Wang BW,Liu D,He GL,Wang H,Duan YJ,Xing JJ,Zhou HY,Zhou YW. 创伤性脑损伤动物模型研究进展[J]. 法医学杂志, 2011, 27(4): 286-9, 294. DOI: 10.3969/j.issn.1004-5619.2011.04.013 |
| 作者姓名： | Li SX Wang BW Liu D He GL Wang H Duan YJ Xing JJ Zhou HY Zhou YW |
| 作者单位： | 1. 华中科技大学同济医学院法医学系,湖北武汉,430030 2. 鄂州市公安局,湖北鄂州,436000 3. 中华人民共和国公安部物证鉴定中心,北京,100038 |
| 基金项目： | 教育部留学回国人员科研启动基金资助项目(2009-35); 中国科学院波谱与原子分子物理国家重点实验室开放基金资助项目(T152909); 中央级科研院所基本科研业务费面上项目(2007jb009) |
| 摘 要： | 创伤性脑损伤(traumatic brain injury,TBI)是多因素作用的高度复杂过程,TBI动物实验研究有利于阐明TBI原发性、继发性损伤机制及病理生理学过程,为诊断及治疗提供依据.动物模型的选择依赖于研究目的,然而各种动物模型均具有局限性,仅能复制TBI关键的损伤机制或某一重要的病理生理学过程而无法全面反映... |
| 关 键 词： | 法医病理学 脑损伤 综述[文献类型] 模型,动物 |
Advance in animal models of traumatic brain injury |
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| Li Shang-Xun,Wang Bo-Wei,Liu Dan,He Guang-Long,Wang Hao,Duan Yi-Jie,Xing Jing-Jun,Zhou Hong-Yan,Zhou Yi-Wu. Advance in animal models of traumatic brain injury[J]. Journal of Forensic Medicine, 2011, 27(4): 286-9, 294. DOI: 10.3969/j.issn.1004-5619.2011.04.013 | |
| Authors: | Li Shang-Xun Wang Bo-Wei Liu Dan He Guang-Long Wang Hao Duan Yi-Jie Xing Jing-Jun Zhou Hong-Yan Zhou Yi-Wu |
| Affiliation: | LI Shang-xun1,WANG Bo-wei2,LIU Dan1,HE Guang-long3,WANG Hao1,DUAN Yi-jie1,XING Jing-jun1,ZHOU Hong-yan1,ZHOU Yi-wu1(1.Department of Forensic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China,2.Ezhou Public Security Bureau,Ezhou 436000,3.Institute of Forensic Science,Ministry of Public Security,P.R.China,Beijing 100038,China) |
| Abstract: | Traumatic brain injury(TBI) is a highly complex multi-factorial disorder.Animal models of TBI are used to elucidate primary and secondary injury mechanisms and pathophysiological changes and to provide the diagnostic and therapeutical basis for TBI.The choices of animal models depend upon the research objectives.However,various animal models have limitations.The models only can duplicate the pivotal injury mechanisms or a certain important pathophysiological course.The characteristics of human TBI can not f... |
| Keywords: | forensic pathology brain injuries review[publication type] models animal |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ | |