Association of a Mixed Anxiety-Depression Syndrome and Symptoms of Major Depressive Disorder During Adolescence

The relations between an empirically derived syndrome of Anxiety-Depression and an analogue measure of Major Depressive Disorder (MDD) are examined in a longitudinal study of a nationally representative sample of adolescents. Analyses of parents' reports and adolescents' self-reports indicate that there is moderate correspondence between scores on the Anxious-Depressed syndrome and symptoms of the MDD Analogue. Furthermore, scores on the syndrome predicted MDD Analogue symptoms 3 years later with sensitivities ranging from .69 to .71 and specificities from .69 to .93. Meeting criteria for either the Anxious-Depressed syndrome or the MDD Analogue was associated with low social or academic competence and high scores on other syndromes of psychopathology. Implications for integration of empirical/dimensional and categorical/diagnostic approaches are highlighted.