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Development of a harmonized method for the profiling of amphetamines. I. Synthesis of standards and compilation of analytical data
Authors:Aalberg Laura  Andersson Kjell  Bertler Christina  Borén Hans  Cole Michael D  Dahlén Johan  Finnon Yvonne  Huizer Henk  Jalava Kaisa  Kaa Elisabet  Lock Eric  Lopes Alvaro  Poortman-van der Meer Anneke  Sippola Erkki
Affiliation:National Bureau of Investigation, P.O. Box 285, FIN-01301 Vantaa, Finland.
Abstract:Reference material was synthesised for 21 substances that are frequently present as synthetic impurities, i.e. by-products, in illicitly produced amphetamine. Each of these substances is a typical by-product for at least one of the three approaches most often used to synthesise amphetamine, namely, the Leuckart, the reductive amination of benzyl methyl ketone, and the nitrostyrene routes. A large body of data on the substances was recorded, including the following: mass spectra, ultraviolet spectra, Fourier transform infrared spectra, infrared spectra in gas phase, and 1H NMR and 13C NMR spectra.
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