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| 青壮年猝死综合征心肌细胞内Cx43的表达 | |
| 引用本文： | 罗斌,程灵犀,林俊莲,刘水平,唐双柏,孔小平,张能培,韩奇杰,汪冠三,许心舒,石河.青壮年猝死综合征心肌细胞内Cx43的表达[J].中国法医学杂志,2010,25(3):159-161. |
| 作者姓名： | 罗斌 程灵犀 林俊莲 刘水平 唐双柏 孔小平 张能培 韩奇杰 汪冠三 许心舒 石河 |
| 作者单位： | 1. 中山大学中山医学院法医学系,广东,广州,510080 2. 中山大学中山医学院法医学系,广东,广州,510080;广州市刑事科学技术研究所,广东,广州,510030 3. 广州市刑事科学技术研究所,广东,广州,510030 4. 东莞市刑科所,广东,东莞,523000 5. 深圳市公安局坪山分局,广东,深圳,518118 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 目的观察连接蛋白43（Cx43）在青壮年猝死综合征（SMDS）者心肌细胞的表达,并探讨其法医学意义。方法筛选法医尸检案例45例,其中SMDS组、冠心病猝死组及对照组各15例。采用免疫组织化学和图像分析技术对不同组别Cx43蛋白在心肌细胞内的表达进行阳性单位（PU）定量检测,分析Cx43蛋白在各组表达的差异。所得数据进行统计学分析。结果 SMDS组心肌Cx43染色明显减弱,阳性着色条带分布不均、深浅不一,有的呈散在颗粒状;冠心病猝死组亦见类似变化;对照组未见明显变化。经统计分析发现,3组心肌细胞内Cx43表达的PU值存在显著性差异（P〈0.05）。结论 SMDS死前存在心肌缺血及心电紊乱,应属心性猝死范畴。 |
| 关 键 词： | 法医病理学 连接蛋白43 青壮年猝死综合征 免疫组织化学 |
Expression of connexin 43 in cardiomyocytes of sudden manhood death syndrome |
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| LUO Bin,CHENG Lingxi,LIN Junlian,LIU Shuiping,TANG Shuangbai,KONG Xiaoping,ZHANG Nengpei,HAN Qijie,WANG Guansan,XU Xinshu,SHI He.Expression of connexin 43 in cardiomyocytes of sudden manhood death syndrome[J].Chinese Journal of Forensic Medicine,2010,25(3):159-161. | |
| Authors: | LUO Bin CHENG Lingxi LIN Junlian LIU Shuiping TANG Shuangbai KONG Xiaoping ZHANG Nengpei HAN Qijie WANG Guansan XU Xinshu SHI He |
| Institution: | (LUO Bin1,CHENG Lingxi1,2,LIN Junlian2,LIU Shuiping1,TANG Shuangbai1,KONG Xiaoping2,ZHANG Nengpei3,HAN Qijie4,WANG Guansan2,XU Xinshu2,SHI He2/1.Department of Forensic Pathology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China,2. Guangzhou Criminal Science and Technology Institute,Guangzhou 510030,3. Dongguan Criminal Science and Technology Institute,Dongguan 523000,4. Pingshan Division of Shenzhen Municipal Public Security Burean,Shenzhen 518118,China) |
| Abstract: | Objective To study the expression of connexin43 (Cx43) in cardiomyocytes in cases of sudden manhood death syndrome(SMDS) and explore its medicolegal significance. Methods Obtained 45 autopsy cases from 3 different groups (SMDS group,coronary atherosclerotic heart disease group and control group). Cx43 protein in myocardium was detected by immunohistochemical techniques. Computerized image analysis was employed to measure the Cx43 positive units(PU) of cardiomyocytes,the data were analyzed statistically. Res... |
| Keywords: | forensic pathology connexin43(Cx43) sudden manhood death syndrome(SMDS) immunohistochemical method |
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