| 代谢组学及其在法医毒理学中的应用 |
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| 引用本文： | 吴明健,王玫,杨瑞琴,张大明. 代谢组学及其在法医毒理学中的应用[J]. 中国法医学杂志, 2013, 28(1): 37-40 |
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| 作者姓名： | 吴明健 王玫 杨瑞琴 张大明 |
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| 作者单位： | 1. 中国人民公安大学,北京,100038
2. 北京市公安局法医检验鉴定中心,北京,100085 |
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| 基金项目： | 公安部重点研究计划项目(2009ZDYJBJSJ001) |
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| 摘 要： | 代谢组学是上世纪90年代中期发展起来的研究细胞和生物体的所有代谢中间体和终产物的一门新兴学科。其研究对象一般为分子量在1 000Da以下的小分子。代谢组学通过对生物体系中的小分子化合物进行定性定量分析,解析生物体系的代谢途径并揭示内源性小分子化合物与毒性、疾病、生命活动规律等的相互关系。本文综述代谢组学的概况及其在法医毒理学中的应用现状,为相关研究和应用提供参考。
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| 关 键 词： | 法医毒理学 代谢组学 应用 |
Metabonomics and its applications in forensic toxicology |
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| Wu Mingjian,Wang Mei,Yang Ruiqin,Zhang Daming. Metabonomics and its applications in forensic toxicology[J]. Chinese Journal of Forensic Medicine, 2013, 28(1): 37-40 |
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| Authors: | Wu Mingjian Wang Mei Yang Ruiqin Zhang Daming |
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| Affiliation: | 1.Chinese People’s Public Security University,Beijing 100038,China;2.Forensic Medical Examination Center of Beijing Public Security Bureau,Beijing 100085,China) |
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| Abstract: | Metabonomics which developed in the mid-1990s is a new science.It studies all metabolic intermediates and end products in cells and organisms.The main object of study is small molecules whose molecular weight below 1 000Da.Metabonomics uses the method which the quantitative analysis and the qualitative analysis unify to study metabolic transit of the biological system and reveal the mutual relations of the small molecule compounds with toxicity,disease,regular patterns of life activities.In this paper,we made an overview of metabonomics and summarized its application in forensic toxicology,which provided reference for related research and applications. |
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| Keywords: | forensic toxicology metabonomics application |
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