急性乙醇中毒者体内乙醇动力学研究

根据乙醇在体内的代谢动力学特点,本文建立了研究急性乙醇中毒者血液乙醇动力学数学模型,其表达式为:x(t)=x_0(1-e-~(kat))-k_bt。从该数学模型可求得乙醇在体内的吸收速率常数(K_a)和消除速率常数(K_b),从而可以获得体内乙醇浓度动态变化曲线。所以,饮用乙醇饮料后的时刻乙醇浓度(x(t))均可由曲线中查得。实验研究证实,以该数学模型导出的参数与实验获得的结果相一致。

STUDY OF THE ALCOHOL KINETICS IN ANIMALS Of ACUTE ALCOHOL POISONING

Based on the kinetics of alcohol metabolism in animal models,the mathematicalmode for studing of the alcohol kinetics in person of the acute alcohol poisoningwas established.This mathematical mode can be expressed as x(t)=x_0(1-e~(-kat))-k_bt,which allows calculating the absorpion constant (k_a) arld breakdown rate constant(k_b) for alcohol the curve in dynamic change of the alcohol concentration followingadministration of a large amount of alcohal can be obtained the amount of alcoholin human body [x,(t)] after drinking can be checked out.from the urine Theexperimental study in monkeys showed that the parameters derived from the mathe-matical mode agued witk the results obtained from the experiments