Triallelic patterns in STR loci used for paternity analysis: evidence for a duplication in chromosome 2 containing the TPOX STR locus |
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| Authors: | Lukka Matti Tasa Gunnar Ellonen Pekka Moilanen Kirsi Vassiljev Vitali Ulmanen Ismo |
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| Affiliation: | Paternity Testing Laboratory, Department of Molecular Medicine, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland. |
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| Abstract: | We report triallelic patterns in several short tandem repeat (STR) loci revealed by routine paternity testing using the commercial AMPFlSTR Profiler and AMPFlSTR SGMplus kits. One case where the TPOX-locus (2p25.3) produced three peaks from the blood sample of a child was analysed further. Quantitative polymerase chain reaction (QPCR) and STR typing of the DNAs of the family trio revealed a large (>1.59 Mb) duplication flanking the TPOX-locus in chromosome 2 in both the mother and child. The implications of such genetic anomalies for paternity testing are discussed. |
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