急性坏死性胰腺炎与死后胰腺自溶病理形态学变化

目的比较大鼠急性坏死性胰腺炎（acute necrotizing pancreatitis,ANP）与各种急性死亡大鼠死后48h胰腺的病理形态学变化,探讨两者的鉴别点。方法参照文献制作ANP和电击、机械性窒息（勒死）、急性毒鼠强中毒动物模型,采用半定量评分和图像分析定量分析,观察死后48h胰腺大体和光镜下组织病理变化。结果ANP组炎细胞浸润、脂肪坏死、钙沉积3项与其他组相比有显著意义（P〈0．05）。结论炎细胞浸润、脂肪坏死、钙沉积是ANP在普通光学显微镜下最重要的特异性形态学病理变化,对区别其他急性死亡和死后自溶胰腺有特别重要意义．

Acute necrotizing pancreatitis and postmortem autolysis of pancreas

Objective To compare the pathomorphologic changes between the pancreas in acute necrotizing pancreatitis(ANP) and that in acute deaths of rats(within 48 hours) so as to find the distinctions.Methods The animal models of ANP and other acute deaths(electroshock,mechanic asphyxia/strangle,and acute poisoning with tetramine) were established according to the criteria.Half-quantitative grading and image quantitative analysis methods were employed to observe the gross and microscopic changes of the pancreases.Results Three features including inflammation infiltrate,fat necrosis and calcium deposit in the ANP group were considerably different from that in other acutely died rat group(P<0.05).Conclusion Inflammation infiltrate,fat necrosis and calcium deposit are the most important pathologic features found in ANP by common light microscope,distinguishing ANP from postmortem pancreatic autolysis.