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Suicide by Self‐Administration of a Drug Mixture (Propofol,Midazolam, and Zolpidem) in an Anesthesiologist: The First Case Report in Italy
Authors:Anna Pia Colucci Ph.D.  Roberto Gagliano‐Candela Ph.D.  Lucia Aventaggiato Ph.D.  Antonio De Donno M.D.   Ph.D.  Sabrina Leonardi M.D.  Giuseppe Strisciullo H.S.D.  Francesco Introna M.D.   Ph.D.
Affiliation:1. Laboratory of Forensic Toxicology of Department of Internal Medicine and Public Health, University of Bari, , Bari, Italy;2. Chief of Laboratory of Forensic Toxicology of Department of Internal Medicine and Public Health, University of Bari, , Bari, Italy;3. Researcher of Laboratory of Forensic Toxicology of Department of Internal Medicine and Public Health, University of Bari, , Bari, Italy;4. Department of Internal Medicine and Public Health, University of Bari, , Bari, Italy
Abstract:The authors report an unusual case of suicide of an anesthesiologist, in which the suicide manner and means depend upon the victim's occupation. This is the first case report published in Italy of a death involving propofol and other drugs. The anesthesiologist was found dead with an empty drip still inserted in the hand and another one near his body. Forensic and toxicological findings suggested that the cause of death was a respiratory depression due to a self‐administration of a rapidly infused lethal drug mixture. Analytical drug quantification was performed by gas chromatography‐mass spectrometry. Blood analysis revealed: zolpidem (0.86 μg/mL), propofol (0.30 μg/mL), midazolam (0.08 μg/mL), thiopental (0.03 μg/mL), and amitriptyline (0.07 μg/mL). Adipose tissue and hair analysis suggested a previous and repeated use of these drugs verifying the fact that in Italy recreational abuse of anesthetic and sedative agents in health care practitioners is becoming an increasing problem.
Keywords:forensic science  forensic toxicology  propofol  zolpidem  suicide  anesthesiologist
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