Methylphenidate and hospitalized adolescents with conduct disorder: Dose effects on classroom behavior,academic performance,and impulsivity

The effects of methylphenidate on hospitalized conduct-disordered (CD) adolescents were examined by using teacher ratings of behavior, a measure of classroom learning, and a test of impulsivity. Twenty-two male adolescents with CD, 12–18 years of age, participated in a double-blind, placebo-controlled, within-subject (crossover) design in which each adolescent received three doses of methylphenidate (10 mg, 15 mg, and 20 mg) and a placebo in a randomly assigned, counterbalanced order. Seven of the adolescents had a comorbid diagnosis of attention deficit hyperactivity disorder. Significant overall medication effects were shown on teacher ratings of conduct, and on number of arithmetic questions correctly completed and time spent. Within the limitations of this study, stimulant actions may be effective for some aspects of CD in the absence of attention deficit hyperactivity disorder, although only for specific measures.This project was supported by BRSG S 07 RR 05364 awarded to Ronald T. Brown by the Biomedical Research Support Grant Program, Division of Research Resources, National Institutes of Health, and by an award from the Emory University Research Fund.Portions of this paper were presented at the 96th annual meeting of the American Psychological Association, Atlanta, Georgia, August 1988.Received his Ph.D. from Georgia State University. His research include attention deficit disorders, psychopharmacology, and pediatric psychology.Received his M.D. from Albert Einstein School of Medicine. His research interests include adolescents and attention deficit disorder.Received his M.Ed. degree from Georgia State University. His research interests are in the area of attention deficit disorder.Received his M.D. from the University of West Virginia. His research interests include autism and attention deficit disorder.