| MAO基因遗传多态性及与精神疾病相关性研究进展 |
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| 引用本文： | 张璐,王保捷,丁梅,庞灏,张津京.MAO基因遗传多态性及与精神疾病相关性研究进展[J].中国法医学杂志,2010,25(4):255-258. |
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| 作者姓名： | 张璐 王保捷 丁梅 庞灏 张津京 |
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| 作者单位： | 中国医科大学法医学院,辽宁,沈阳,110001 |
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| 基金项目： | 辽宁省教育厅高等学校科研计划项目 |
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| 摘 要： | 单胺氧化酶(monoamine oxidase,MAO)是调控儿茶酚胺和5-羟色胺等单胺类氧化脱氨的一类重要酶,广泛分布于包括神经系统在内的人体各种组织中,具有多种生物学功能。MAO有两种类型,MAO-A和MAO-B。MAO基因具有遗传多态性,其中部分多态性位点与某些精神疾病如严重抑郁障碍、酒精中毒、反社会情感障碍及精神分裂症等有一定的相关性。MAO基因遗传多态性的研究,可能为法医学个人识别与亲权鉴定提供新的遗传标记,并为司法精神病鉴定提供参考性遗传学指标。
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| 关 键 词： | 法医精神病学 单胺氧化酶 多态性 精神疾病 个人识别 |
Polymorphisms of monoamine oxidase gene and its correlation with certain psychiatric disorders |
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| ZHANG Lu,WANG Baojie,DING Mei,PANG Hao,ZHANG Jinjing.Polymorphisms of monoamine oxidase gene and its correlation with certain psychiatric disorders[J].Chinese Journal of Forensic Medicine,2010,25(4):255-258. |
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| Authors: | ZHANG Lu WANG Baojie DING Mei PANG Hao ZHANG Jinjing |
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| Institution: | Department of Forensic Medicine,China Medical University,Shenyang 110001,China |
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| Abstract: | Monoamine oxidase(MAO) is a kind of mitochondrial outer membrane enzyme that degrades biogenic amines,such as catecholamine and serotonin.It has a variety of biological functions,and can be found in various human tissues,including nervous system.Two MAO enzymes,MAO-A and MAO-B have been identified.MAO gene has polymorphisms,and some of which have a close relationship with certain psychic diseases,such as major depression,alcoholism,antisocial personality disorder and so on.MAO gene can acts as a new forensic individual identification and parentage testing genetic marker or legal psychiatry testing referential genetic marker. |
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| Keywords: | forensic psychiatry monoamine oxidase(MAO) polymorphisms psychiatric disorder individual identification |
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