The diagnosis of diffuse axonal injury in routine autopsy practice |
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| Authors: | R H Simpson D S Berson H A Shapiro |
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| Affiliation: | 1. Department of Neuropathology, School of Pathology of the University of the Witwatersrand and the South African Institute for Medical Research, P.O. Box 1038, Johannesburg, 2000 Transvaal, South Africa;2. Department of Forensic Medicine, University of the Witwatersrand and Department of Health, Welfare and Pensions, Johannesburg, South Africa;3. University of South Africa, and Department of Forensic Medicine, University of the Witwatersrand, Johannesburg, South Africa |
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| Abstract: | A 40-year-old pedestrian was involved in a road traffic accident. He lost consciousness immediately and remained comatose for 6 months until he died of a bronchopneumonia. Examination of the fixed brain revealed the late results of diffuse axonal injury. Not all the features were readily visible macroscopically, but required a limited number of histological sections from readily predictable sites for demonstration. Special stains played only a confirmatory role. This case illustrates some of the problems in diagnosing one of the commoner patterns of brain damage in head injury, and shows how the problem may best be approached in practice. |
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| Keywords: | Autopsy Diffuse axonal injury Head injury |
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