| VNTR遗传标记的亲权鉴定研究 |
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| 引用本文： | 李小明,李生斌.VNTR遗传标记的亲权鉴定研究[J].中国法医学杂志,1996(4). |
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| 作者姓名： | 李小明 李生斌 |
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| 作者单位： | 西安医科大学!710061 |
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| 基金项目： | 国家自然科学基金!39200141 |
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| 摘 要： | 采用Amp－FLP技术研究人类血液、组织VNTR位点D1S80（pMCT118）、D17S30（pCNZ－22）和ApoB3’位点的遗传多态性，并应用于亲权鉴定案件，获得满意结果。D1S80、D17S30和ApoB3’的DP值分别为0．962、0．956和0．960，累积父权排除率（EPP）为94．51％，远远高于传统血型的DP值和EPP值，是亲权鉴定和个体识别有效方法。
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| 关 键 词： | D1S80 D17S30 ApoB3′ 扩增片段长度多态性（Amp－FLP） 亲权鉴定 |
PATERNITY TESTING BY ANALYSIS OF THREE VNTR GENETIC MARKERS |
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| Li Xiaoming, Li Shengbin.PATERNITY TESTING BY ANALYSIS OF THREE VNTR GENETIC MARKERS[J].Chinese Journal of Forensic Medicine,1996(4). |
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| Authors: | Li Xiaoming Li Shengbin |
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| Abstract: | The polymorphisms of VNTR loci D1S80 (pMCT 118), D17S30 (pYNZ-22 ) and ApoB3' in blood and tissues were detected by amplified fragment length polymorphism (Amp-FLP) technique,and was applied in the paternity testing cases. The discriminating power (DP) of D1S80,D17S30 and ApoB3'were 0. 962, 0. 956 and 0. 960 respectively. The cumulative probability of paternity exclusion (EPP) of the three VNTR loci was 94. 51 %,higher than that of conventional blood typings. |
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| Keywords: | D1S80 D17S30 ApoB3′ Amp-FLP technique paternity testing |
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