Development and validation of a liquid chromatography–mass spectrometry assay for hair analysis of methylphenidate |
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| Authors: | E Marchei JA Muñoz Ó García-Algar M Pellegrini O Vall P Zuccaro S Pichini |
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| Institution: | 1. Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, V.le Regina Elena 299, 00161 Rome, Italy;2. Pediatric Service, Hospital Universitari del Mar, Barcelona, Spain;3. Unitat de Recerca Infància i Entorn (URIE), Hospital Universitari del Mar, Barcelona, Spain |
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| Abstract: | Methylphenidate (MPH) is a phenethylamine derivative used in the treatment of childhood attention-deficit hyperactivity disorder. MPH is biotransformed in the body by the hydrolysis of the methyl ester linkage to its metabolite, ritalinic acid. Whereas both compounds are usually measured in plasma and urine, preliminary observations show that only the parent compound is present in hair from treated individuals. |
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| Keywords: | Hair Methylphenidate LC&ndash MS |
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