| 大麻的体内代谢物THC—COOH的分析 |
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| 引用本文： | 向平,沈敏. 大麻的体内代谢物THC—COOH的分析[J]. 法医学杂志, 1996, 12(4): 197-200 |
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| 作者姓名： | 向平 沈敏 |
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| 作者单位： | 司法部司法鉴定科学技术研究所 |
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| 摘 要： | 本文介绍了定性定量分析大麻的主要代谢物ＴＨＣ－ＣＯＯＨ的两种方法。所有试管硅烷化，尿样碱性水解。ＴＬＣ法快速、简便，适用于多份检材的同时定性分析，最低检测限为５０ｎｇ．采用衍生化、ＳＩＭ的ＧＣ／ＭＳ方法灵敏，选择性、专一性强．五氟丙酸酐衍生化方法线性范围为２０－２５０ｎｇ／ｍｌ，最低检测限１０ｎｇ／ｍｌ，变异系数为８．４％，提取回收率为５８．９％；甲基化方法线性范围１０～１００ｎｇ／ｍｌ，最低检测限５ｎｇ／ｍｌ，变异系数为５．６％，提取回收率为５３．２％．
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| 关 键 词： | 薄层色谱；气－质联用仪；△~9－四氢大麻酸；硅烷化；衍生化 |
Analysis of the Main Cannabis Metabolite THC-COOH |
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| Xiang Ping,Shen Min and Shen Baohua. Analysis of the Main Cannabis Metabolite THC-COOH[J]. Journal of Forensic Medicine, 1996, 12(4): 197-200 |
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| Authors: | Xiang Ping Shen Min Shen Baohua |
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| Abstract: | A procedure of detection and quantitation of THC-COOH,a major metabolite of THC in urine. has been described.Prior to extraction,the tubes must be silanized.The hydrolysis of urine is necessary.Derivatizing and selected ion monitoring are oboed out to increase the sensitivity of detection.TLC is rapid for a large number of sample analysises.The method of GC/MS is sensitive.selective and specific. |
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| Keywords: | TLC GC/MS THC-COOH silanize derivatize |
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