| 血液中丙泊酚的GC-MS分析 |
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| 作者姓名： | Zhu YJ Ding XK |
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| 作者单位： | 1. 湖州市人民检察院,浙江,湖州,313000
2. 丽水市人民检察院,浙江,丽水,323000 |
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| 摘 要： | 目的应用气质联用仪(GC-MS),建立快速、灵敏地分析血液中丙泊酚的定性定量方法。方法血液1mL,加入内标,采用液液提取方法处理,GC-MS选择离子(SIM)模式测定。结果在0.1～10μg/mL范围呈良好的线性关系,相关系数R2为0.9931,最低检测限(LOD)为0.05μg/mL。结论所建立的方法简便、快速、特异性强、灵敏度高,可满足法庭毒物分析和临床毒物分析的需要。
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| 关 键 词： | GC-MS 丙泊酚 血液 |
| 文章编号： | 1004-5619(2006)04-0314-02 |
| 修稿时间： | 2006年6月26日 |
Development of a gas chromatography-mass spectrometry method for the quantification of propofol in blood |
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| Zhu YJ,Ding XK.Development of a gas chromatography-mass spectrometry method for the quantification of propofol in blood[J].Journal of Forensic Medicine,2006,22(4):313-314. |
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| Authors: | Zhu You-Jiang Ding Xuan-Kun |
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| Institution: | The people's Procuratorate of Huzhou, Huzhou 313000, China. |
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| Abstract: | OBJECTIVE: A rapid and selective method has been developed for the determination of propofol in blood by gas chromatography-mass spectrometry (GC-MS). METHODS: The blood was extrasted with the solution of internal standard, the extracted residue was analyzed by gas chromatography-mass spectrometry using selected-ion monitoring mode. RESULTS: The linear range was 0.1-10 microg/mL. The coefficient(R2) was 0.993 1. The detection limit was 0.05 microg/mL. CONCLUSION: The method is simple and rapid, offering superior sensitivity and selectivity for propofol. The method can be used successfully during clinical and forensic toxicology. |
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| Keywords: | GC-MS propofol blood |
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