| 猪传染性胸膜肺炎三价灭活疫苗的研究--菌种选择、疫苗制备及安全性试验 |
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| 引用本文： | 逯忠新,赵萍,邵英德,柳纪省,鲁炳义,邱昌庆,李宝玉,叶培根,陈焕春,吴斌. 猪传染性胸膜肺炎三价灭活疫苗的研究--菌种选择、疫苗制备及安全性试验[J]. 中国兽医科学, 2002, 32(3): 7-9 |
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| 作者姓名： | 逯忠新 赵萍 邵英德 柳纪省 鲁炳义 邱昌庆 李宝玉 叶培根 陈焕春 吴斌 |
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| 作者单位： | 1. 中国农业科学院,兰州兽医研究所,甘肃,兰州,730046
2. 华中农业大学畜牧兽医学院,湖北,武汉,430070 |
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| 基金项目： | 国家“九五”重点科技项目子专题 (96 0 0 3 0 4 1 1 0 1 ) |
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| 摘 要： | 以国内多发的猪传染性胸膜肺炎放线杆菌 (APP) 1、3、7血清型强毒株作为制苗菌株 ,制成油佐剂三价灭活苗。经效力试验 ,对上述 3种血清型强毒攻击的保护率分别为 88.8%、88.8%和 10 0 % ;试验动物安全性检验及田间安全检验 ,除个别猪出现轻微体温反应及暂时减食外 ,无其他异常反应。表明该苗对猪的保护性及安全性良好
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| 关 键 词： | 猪传染性胸膜肺炎 放线杆菌 三价灭活苗 免疫效力 安全性 |
| 文章编号： | 1000-6419(2002)03-0007-03 |
| 修稿时间： | 2001-11-12 |
Study on the inactivated trivalent vaccine against swine infectious pleuropneumoniae: selection of the seed strain, preparation and safety trials of the vaccine |
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| LU Zhong xin ,ZHAO Ping ,SHAO Ying de ,LIU Ji xing ,LU Bing yi,QIU Chang qing,LI Bao yu ,YE Pei gen ,CHEN Huan chun ,WU Bin. Study on the inactivated trivalent vaccine against swine infectious pleuropneumoniae: selection of the seed strain, preparation and safety trials of the vaccine[J]. Chinese Veterinary Science, 2002, 32(3): 7-9 |
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| Authors: | LU Zhong xin ZHAO Ping SHAO Ying de LIU Ji xing LU Bing yi QIU Chang qing LI Bao yu YE Pei gen CHEN Huan chun WU Bin |
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| Affiliation: | LU Zhong xin 1,ZHAO Ping 1,SHAO Ying de 1,LIU Ji xing 1,LU Bing yi,QIU Chang qing,LI Bao yu 1,YE Pei gen 2,CHEN Huan chun 2,WU Bin 2 |
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| Abstract: | Many batchs of inactivated trivalent vaccines were prepared using Actinobacillus pleuropneumoniae serotyses 1,3 and 7 which are predominant prevalent virulent isolates in China as the vaccine strains. The potency tests proved that the protective rates of the vaccines against the above three virulent serotype strains challenging reached 88.8%, 88.8% and 100%, respectively. In the safety tests of laboratory and field, only several of pigs immunized with the vaccines showed a little fever reaction and temporal anorexia without any another abnormal reaction, which confirmed that the immunity efficacy and safety of the vaccine were better. |
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| Keywords: | swine infectious pleuropneumoniae Actinobacillus inactivated trivalent vaccine immunity potency safety |
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