Tissue distribution of DDVP after fatal ingestion |
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| Institution: | 1. Graduate School of Horticulture, Chiba University, 648 Matsudo, Chiba 271-8510, Japan;2. Ibaraki Nature Museum, 700 Osaki, Bando, Ibaraki 306-0622, Japan;3. Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, CAS, Kunming 650204, China;4. Musashino School of Paleontology, 3-20-7 Chuo, Musashi-murayama, Tokyo 208-0003, Japan;5. Graduate School of Environment and Information Sciences, Yokohama National University, 79-7 Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japan;1. Northwest Institute for Nonferrous Metal Research, Xi''an 710016, China;2. Xi''an University of Architecture and Technology, Xi''an 710055, China;3. Xi''an Advanced Medical Technology Co., Ltd., Xi''an 710077, China |
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| Abstract: | Tissue distribution of dichlorvos (DDVP) was determined in a case of fatal ingestion using a rapid and simple gas chromatographic (GC) assay. Remarkable autopsy findings were congestion of the lung and kidneys and bleeding ulcer extending from the dorsum of the tongue to the upper pharynx. The serum cholinesterase activity was 2 IU/l, however, miosis was not observed. In the stomach, 250 ml of volatile fluid was found. Tissue distribution of DDVP was determined using a newly developed simple and rapid GC method. DDVP was found in the spleen and heart at higher concentrations (3340 and 815 μg/g, respectively), and also detected in the urine at the lowest level (4.5 μg/ml). The DDVP concentrations in blood, brain, lung, kidney and liver were 29, 9.7, 81, 80 and 20 μg/ml or g, respectively. |
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