Fourier-transformed infrared breath testing after ingestion of technical alcohol |
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Authors: | Laakso Olli Haapala Matti Pennanen Teemu Kuitunen Tapio Himberg Jaakko-Juhani |
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Affiliation: | 1. Department of Anesthesiology and Intensive Care Medicine, Hyvink?? Hospital, Hyvink??, Finland.;2. Division of Anesthesiology and Intensive Care Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland.;3. Temet Instruments Ltd., Helsinki, Finland.;4. Laboratory of Physical Chemistry, University of Helsinki, Helsinki, Finland.;5. Department of Medicine, Jorvi Hospital, Espoo, Finland.;6. HUSLAB, Helsinki, Finland. |
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Abstract: | The study aim was to evaluate the feasibility of a Fourier-transformed infrared (FT-IR) analyzer for out-of-laboratory use by screening the exhalations of inebriated individuals, and to determine analysis quality using common breath components and solvents. Each of the 35 inebriated participants gave an acceptable sample. Because of the metabolism of 2-propanol, the subjects exhaled high concentrations of acetone in addition to ethanol. Other volatile ingredients of technical ethanol products (methyl ethyl ketone, methyl isobutyl ketone, and 2-propanol) were also detected. The lower limits of quantification for the analyzed components ranged from 1.7 to 12 microg/L in simulated breath samples. The bias was +/-2% for ethanol and -11% for methanol. Within-day and between-day coefficients of variation were <1% for ethanol and <4% for methanol. The bias of ethanol and methanol analyses due to coexisting solvents ranged from -0.8 to +2.2% and from -5.6 to +2.9%, respectively. The FT-IR method proved suitable for use outside the laboratory and fulfilled the quality criteria for analysis of solvents in breath. |
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Keywords: | forensic science forensic medicine breath tests ethanol methanol solvents spectrophotometry infrared false‐positive reactions |
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