肉用鸡垂体-肾上腺轴与免疫功能关系的研究

以艾维茵肉鸡为试验动物,研究了垂体-肾上腺轴在传染性腔上囊病病毒(IBDV)强毒株攻击时对免疫系统的调节作用.结果表明,用IBDV强毒株攻击后,试验鸡垂体-肾上腺轴活动加强,血清促肾上腺皮质激素(ACTH)和皮质酮(F)上升,抗IBDV抗体、白细胞介素2(IL-2)和白细胞介素3(IL-3)上升,T淋巴细胞转化率下降.未经IBD疫苗免疫的鸡由于免疫系统遭到IBDV破坏,在IBDV强毒株攻毒后,抗IBDV抗体、IL-2和IL-3的上升幅度均比经IBD疫苗免疫的低.试验鸡血清ACTH和F分别与抗IBDV抗体、IL-2和IL-3呈显著正相关,与T淋巴细胞转化率呈显著负相关,显示机体受病原微生物攻击后垂体-肾上腺轴对免疫系统的调节作用,即增强特异性免疫反应,抑制非特异性免疫细胞的扩增.

Relationship between pituitary-adrenal axis and immune function in broiler

Avian broilers were used as experimental objects to study the mechanism of the pituitary adrenal axis regulating immune system when being infected with virulent infectious bursal disease virus (IBDV). The results showed that after IBDV infecting, the pituitary adrenal axis activation became strong, i.e. serum cortiscosterone (F) and adrenocortiscotropic hormone (ACTH) increased, and in the meantime, the serum antibody against IBDV, the activities of IL 2 and IL 3 increased too, but the transformation rate of T lymphocyte decreased. After virulent IBDV challenging, the rising extents of the serum antibody to IBDV, the activities of IL 2 and IL 3 of the brolilers not immunized with IBDV vaccine owing to being subjected to destruction of the immune system were less than that of the broilers immunized with IBDV vaccine. The serum ACTH and F had closely positive correlations with the serum antibody titer to IBDV and the activities of IL 2 and IL 3, but closely negative correlation with the transformation rate of T lymphocyte, which revealed that pituitary adrenal axis is able to modulate the immune system after chickens have been infected with virulent IBDV, i.e., improving specific immunity response via supressing reproduction of nonspecific immune cells.