Isolation and characterisation of a novel sildenafil analogue adulterant,desmethylpiperazinyl propoxysildenafil,in a dietary supplement |
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Authors: | Ji Hyun Lee Han Na Park Aeran Jung Suresh Mandava Seongsoo Park Jongkook Lee Hoil Kang |
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Affiliation: | 1. Division of Advanced Analysis, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju-si, Chungcheongbuk-do 28159, Republic of Korea;2. College of Pharmacy, Kangwon National University, 1 Kangwondaehak-gil Chuncheon, Gangwon-do 24341, Republic of Korea |
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Abstract: | A new sildenafil analogue was detected during routine screening of dietary supplements suspected to be adulterated with an erectile dysfunction drug(s) using HPLC-DAD. The UV spectrum of this compound was highly similar to that of sildenafil and almost identical to that of desmethylpiperazinyl sildenafil. The analogue was purified by using semi-preparative HPLC and structurally elucidated by performing mass spectrometric and NMR spectroscopic experiments. The spectral data revealed that this sildenafil analogue bears an n-propoxy group instead of an ethoxy group and possesses no methylpiperazinyl moiety. The isolated compound, structure of which was further confirmed by spectral comparison with synthetic one, was thus named as desmethylpiperazinyl propoxysildenafil. |
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Keywords: | Dietary supplement Sildenafil analogue Desmethylpiperazinyl propoxysildenafil PDE5 inhibitor Erectile dysfunction |
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