Non-linear kinetics of ethanol elimination in man: Medico-legal applications of the terminal concentration-time data analysis |
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Authors: | R. Bruno A. Iliadis M.J. Treffot B. Mariotti J.P. Cano G. Jullien |
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Affiliation: | 1. Laboratoire de Médicine Légale, UER de Médecine, Marseille, France;2. INSERM SCN No. 16, Pharmacocinétique et Toxicocinétique, UER de Pharmacie, Marseille France;3. Service de Gastroenterologie, Hôpital de la Conception, Marseille France |
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Abstract: | Research regarding parameters suitable for reporting on the activity of enzymatic systems responsible for ethanol metabolism is of obvious interest in medico-legal practice. Blood ethanol concentration-time curves, following oral administration of ethanol, have been developed for ethylic and non-ethylic subjects. This study has confirmed the non-linear kinetics of ethanol elimination; however, existing non-linear models appear to be inadequate for usual medico-legal practice, because of their complexity. We observed three phases during the elimination of ethanol. The first order terminal phase is characterized by its half-life. This parameter seems adequate as a basis for determining the activity of enzyme systems responsible for the metabolism of ethanol. |
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Keywords: | Ethanol Man Medico-legal Non-linear kinetics |
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