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Simulating Emotional Responses in Posttraumatic Stress Disorder: An fMRI Study |
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| Authors: | Richard A. Bryant Andrew Kemp Kim Felmingham Belinda Liddell Gloria Olivieri Anthony Peduto Evian Gordon Leanne M. Williams |
| Affiliation: | 1. Brain Dynamics Centre, Westmead Millennium Institute, Sydney, Australia 2. School of Psychology, University of New South Wales, Sydney, New South Wales, 2052, Australia 3. Department of Radiology, Westmead Hospital, Westmead, Australia 4. Brain Resource International Database, Brain Resource Company, Sydney, Australia 5. Discipline of Psychological Medicine, Western Clinical School, University of Sydney, Sydney, Australia |
| Abstract: | This study tested the extent to which coached participants can simulate the neural responses of participants with posttraumatic stress disorder (PTSD) when they are presented with signals of fear. Functional magnetic resonance imaging (fMRI) was used to study blood oxygenation level-dependent signal during the presentations of fearful and neutral faces under both conscious and nonconscious (masked) conditions. Participants comprised 12 patients with PTSD and 12 trauma-exposed controls who were instructed to simulate PTSD. During conscious fear processing, simulators showed greater activation in the left amygdala and medial prefrontal cortex (MPFC) than PTSD participants. By contrast, during nonconscious processing, PTSD participants had greater MPFC activation than simulators. These findings suggest that coached simulators produce a profile of ‘over-responding’ to fear when controlled conscious processing is possible, but are not able to simulate the exaggerated medial prefrontal responses observed in PTSD participants under conditions of nonconscious processing. |
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