Atrial natriuretic peptide signal pathway upregulated in stomach of streptozotocin-induced diabetic mice |
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Authors: | Young-Chul Kim |
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Affiliation: | Department of Physiology Chungbuk National University College of Medicine |
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Abstract: | AIM:To investigate atrial natriuretic peptide(ANP) secretion from gastric mucosa and the relationship between the ANP/natriuretic peptide receptor type A (NPR-A)pathway and diabetic gastroparesis. METHODS:Male imprinting control region(ICR)mice (4 wk old)were divided into two groups:control mice, and streptozotocin-induced diabetic mice.Eight weeks after injection,spontaneous gastric contraction was recorded by using physiography in control and streptozotocin-induced diabetic mice.The ANP-positive cells in ... |
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Keywords: | Diabetes mellitus Atrial natriuretic peptide Gastric mucosa Gastroparesis |
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