| 外周血DNA甲基化谱与吸烟的关系 |
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| 引用本文： | 毕钢,曹禹,胡伟,沈玮玮,周怀谷,刘赟. 外周血DNA甲基化谱与吸烟的关系[J]. 中国法医学杂志, 2017, 0(5): 508-511. DOI: 10.03618/j.issn.1001-5728.2017.05.017 |
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| 作者姓名： | 毕钢 曹禹 胡伟 沈玮玮 周怀谷 刘赟 |
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| 作者单位： | 1. 上海市公安局物证鉴定中心,上海,200083;2. 上海市公安局松江分局刑事科学技术研究所,上海,201600;3. 复旦大学基础医学院生物化学与分子生物学系,上海,200032 |
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| 基金项目： | 国家自然科学基金面上项目(31471212) |
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| 摘 要： | 目的通过比较吸烟与不吸烟个体外周血DNA甲基化谱的差异,评估DNA甲基化在区分吸烟与不吸烟人群中的应用价值。方法根据下载于NIH的GEO公共数据库的人类全基因组DNA甲基化数据,运用Student’s T检验和聚类分析的方法评估外周血特定CpG位点DNA甲基化程度在吸烟与不吸烟人群中的差异。结果特定Cp G位点上,非吸烟人群与吸烟人群的DNA甲基化有显著区别。结论检测人外周血的甲基化情况可以区分吸烟和非吸烟人群。
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| 关 键 词： | 法医物证学 甲基化 个体识别 吸烟人群 |
The relationship between DNA methylation profile of peripheral blood and smoking |
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| Bi Gang,Cao Yu,Hu Wei,Sheng Weiwei,Zhou Huaigu,Liu Yun. The relationship between DNA methylation profile of peripheral blood and smoking[J]. Chinese Journal of Forensic Medicine, 2017, 0(5): 508-511. DOI: 10.03618/j.issn.1001-5728.2017.05.017 |
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| Authors: | Bi Gang Cao Yu Hu Wei Sheng Weiwei Zhou Huaigu Liu Yun |
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| Abstract: | Objective To evaluate the potential application of separating smoking individuals from non-smoking ones by DNA methylation profiles from peripheral blood. Methods Human genome-wide DNA methylation data were downloaded from NIH GEOdata base. DNA methylation values from certain CpG sites were used to evaluate their significance between smokers and non-smokers by Student's T Test, as well as the clustering analysis. Results There are significant DNA methylation between smokers and non-smokers for certain CpGs. Conclusion Detection of methylation status from human peripheral blood can distinguish smokers from non-smokers. |
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| Keywords: | forensic biological evidence methylation individual identification smoking population |
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