| 二代测序技术在法医学中的应用 |
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| 引用本文： | 张雯,程宝文,许冰莹. 二代测序技术在法医学中的应用[J]. 中国法医学杂志, 2017, 0(1): 40-43. DOI: 10.13618/j.issn.1001-5728.2017.01.011 |
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| 作者姓名： | 张雯 程宝文 许冰莹 |
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| 作者单位： | 1. 昆明医科大学,云南 昆明 650500;云南省公安厅,云南 昆明 650228;2. 云南省公安厅,云南 昆明,650228;3. 昆明医科大学,云南 昆明,650500 |
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| 基金项目： | 国家自然科学基金 (81260467 |
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| 摘 要： | 随着二代测序技术的快速发展,其高通量和低成本在生命科学领域应用广泛,测序的通量更高,测序时间和成本不断下降,使得其被广泛应用于微生物研究、古DNA研究、临床诊断、法医学研究等。本文阐述了二代测序技术平台及其遗传标记在法医学中的应用,包括STR分型、SNP分型、HLA基因型预测以及在降解检材中的应用等。
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| 关 键 词： | 法医物证学 二代测序技术(NGS) STR SNP HLA |
Application of next-generation sequencing technology in forensic science |
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| Zhang Wen,Cheng baowen,Xu Bingying. Application of next-generation sequencing technology in forensic science[J]. Chinese Journal of Forensic Medicine, 2017, 0(1): 40-43. DOI: 10.13618/j.issn.1001-5728.2017.01.011 |
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| Authors: | Zhang Wen Cheng baowen Xu Bingying |
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| Abstract: | With the rapid development of Next-generation Sequencing(NGS)technologies, and its high throughput and low cost is applied widely in the field of life science, the increase in the depth of sequencing together decrease in the consumption of time and cost, makes a wide application of NGS in the research of microbiological research, ancient DNA study, clinical diagnosis, forensic science research, etc. The article discusses the second generation sequencing technology platform and its genetic markers in the forensic application. Included STR typing, SNP typing, HLA genotype prediction and the application in the degradation of the material. |
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| Keywords: | forensic biological evidence next generation sequencing STR SNP HLA |
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