| 脑钠尿肽的表达调控机制及其法医学应用 |
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| 引用本文： | 田美慧,曹志鹏,雒心怡,薛嘉嘉,肖莹,贾宇晴,朱宝利. 脑钠尿肽的表达调控机制及其法医学应用[J]. 中国法医学杂志, 2017, 0(5): 472-475. DOI: 10.03618/j.issn.1001-5728.2017.05.008 |
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| 作者姓名： | 田美慧 曹志鹏 雒心怡 薛嘉嘉 肖莹 贾宇晴 朱宝利 |
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| 作者单位： | 中国医科大学法医学院,辽宁 沈阳,110122 |
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| 基金项目： | 国家自然科学基金资助项目(81273343) |
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| 摘 要： | 脑钠尿肽是主要由心肌细胞分泌的钠尿肽类激素,通常在心肌细胞受到牵拉时产生,具有利钠、利尿、舒张血管、调节血压等功能。临床上BNP是反映心功能的重要指标之一,近年的研究表明,BNP在法医学中对心源性猝死的诊断也具有十分重要的价值。本文综述了BNP的分子结构、表达调控及法医学应用的进展。
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| 关 键 词： | 法医病理学 脑钠尿肽 表达调控 心源性猝死 |
Expression regulation and forensic application of Brain Natriuretic Peptide |
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| Tian Meihui,Cao Zhipeng,Luo Xinyi,Xue Jiajia,Xiao Ying,Jia Yuqing,Zhu Baoli. Expression regulation and forensic application of Brain Natriuretic Peptide[J]. Chinese Journal of Forensic Medicine, 2017, 0(5): 472-475. DOI: 10.03618/j.issn.1001-5728.2017.05.008 |
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| Authors: | Tian Meihui Cao Zhipeng Luo Xinyi Xue Jiajia Xiao Ying Jia Yuqing Zhu Baoli |
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| Abstract: | Brain natriuretic peptide (BNP), a natriuretic peptide hormone, is mainly secreted by cardiomyocytes when they are pulled by mechanical force. BNP acts to increase natriuresis and decrease vascular resistance, thereby decreasing blood volume, systemic blood pressure and afterload. It is not only the main indicators of cardiac function which is widely used in clinical, recent studies have also shown that it has a very important value in identifying sudden cardiac death(SCD). However, the exact expression of the regulation mechanism is still unknown. This paper reviewed the structure, expression of the regulation mechanism of BNP, and the application progress in clinical and forensic. |
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| Keywords: | forensic pathology brain natriuretic peptide expression regulation sudden cardiac death |
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