A rapid method of screening blood and urine samples for narcotic analgesics |
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| Authors: | W Pe |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Islamic Republic of Iran;2. Peoples’ Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya Street, Moscow 117198, Russian Federation;3. Institute of Chemistry, Saint-Petersburg State University, 26 University Prosp St. Peterhof, Saint Petersburg, 198504, Russian Federation;4. Tver’ State University, 33, Zhelyabova Street, Tver, 170100, Russian Federation;1. Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA;2. Department of Medicinal Chemistry, Faculty of Pharmacy, Omar Al-Mukhtar University, El-Beida, Libya;3. Forensic Spectral Research, Bridgeton, NJ 08302, USA;4. Department of Chemistry, College of Science, Eastern Kentucky University, Richmond, KY 40475, USA;5. Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt;1. Institute of Pharmaceutical and Medicinal Chemistry, University of Münster, Corrensstr. 48, D-48149 Münster, Germany;2. Institute for Genetics of Heart Diseases (IfGH), Department of Cardiovascular Medicine, University Hospital Muenster, D-48149 Muenster, Germany;3. Cells-in-Motion Cluster of Excellence (EXC 1003 – CiM), University Münster, Germany;1. Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea;2. State Key laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 210009, China;3. Department of Energy Systems Research, Ajou University, Suwon 443-749, Korea;1. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark;2. Department of Biomedical and Pharmaceutical Sciences, Center for Biomolecular Structure and Dynamics, Center for Structural and Functional Neuroscience, University of Montana, 32 Campus Dr, Missoula, MT 59812, United States;1. Institute of Neuropathology, University of Zürich, CH-8091 Zürich, Switzerland |
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| Abstract: | A simple, rapid method for detection of heroin and its metabolites in blood and urine is described. The technique employs alkaline hydrolysis in an autoclave for 15 minutes followed by two-dimensional TLC using ethyl acetate :methanol :ammonia (85:10:5) and ethanol :dioxane :benzene :ammonia (5:40:50:5) as developing solvent systems. Visualization of spots is by ferric chloride/ferricyanide spray. Incomplete hydrolysis of the alcoholic 6-acetyl morphine metabolite was found, aiding reliable identification. No dealkylation of codeine occurred during the hydrolysis step. |
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