Length variation in HV2 of the human mitochondrial DNA control region. |
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Authors: | J E Stewart C L Fisher P J Aagaard M R Wilson A R Isenberg D Polanskey E Pokorak J A DiZinno B Budowle |
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Affiliation: | DNA Analysis Unit II, FBI Laboratory, Washington, DC 20535, USA. |
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Abstract: | Hair samples were typed from three individuals who exhibited length heteroplasmy in the homopolymeric cytosine stretches (C-stretch) in hypervariable region 2 (HV2). The study demonstrated that for different hairs within an individual, the HV2 C-stretch region can vary with respect to the number of cytosines and/or proportion of C-stretch length variants. Length heteroplasmy may occur regardless of the prominent length variant present in this region. Differences in the number of cytosines at the C-stretch region, or a variation in the relative amounts of heteroplasmic length variants, cannot be used to support an interpretation of exclusion. |
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