| Abstract: | A technique of a rapid urine dimedrol assay by gradient microcolon high performance liquid chromatography is proposed. Dimedrol is detected selectively in the presence of large amounts of medicinal and narcotic substances metabolites. Threshold of detectability was 0.005 mcg/ml, optimal range of quantitation -0.02 - 1 mcg/ml, extraction degree in sampling -85%. It was found that concentration of dimedrol in the urine obtained for chemicotoxicological tests ranges from 0.01 to 2.5 mcg/ml. Establishment of dimedrol intake by presence of its metabolites was studied. |
