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The impurity characteristics of methamphetamine synthesized by Emde and Nagai method
Authors:Beom Jun Ko  SungIll Suh  Yong Jun Suh  Moon Kyo In  Sung-Hong Kim
Institution:aDrug Signature Analysis Center, Supreme Prosecutors’ Office, 706, Banporo, Seochogu, Seoul 137-730, Republic of Korea;bSchool of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Republic of Korea;cKorea Basic Science Institute, Daegu branch, Daegu 702-701, Republic of Korea
Abstract:Impurity profiling and classification of seized methamphetamine may play an important role in the interpretation of analytical results, the determination of the synthetic method employed, and the criminal investigations of drug traffic routes. Our study is focused on classifying seized methamphetamine samples according to the groups sorted by the types and quantities of impurities present in illicit methamphetamine samples. The samples (100 mg) were dissolved in 2 mL of potassium phosphate buffer (pH 7.0), extracted with 200 μL of ethyl acetate under basic condition, and then analyzed by gas chromatography-mass spectrometry (GC–MS) with a DB-1 capillary column (30 m × 0.25 mm i.d., 0.25 μm). Five impurities are used as criteria for the classification of seized methamphetamine samples by Emde and Nagai method. A total of fifty-two samples of seized methamphetamine were analyzed by GC–MS and classified by five organic impurities, and then sorted into four groups, which are Nagai type, Emde Type, Undetermined I type, and Undetermined II type.
Keywords:Methamphetamine  Impurity profiling  Emde method  Nagai method
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