Determination of salvinorin A and salvinorin B in Salvia divinorum-related products circulated in Japan |
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| Authors: | Kenji Tsujikawa Kenji Kuwayama Hajime Miyaguchi Tatsuyuki Kanamori Yuko T. Iwata Takemi Yoshida Hiroyuki Inoue |
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| Affiliation: | aNational Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba 277-0882, Japan;bSchool of Pharmaceutical Science, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan |
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| Abstract: | Two major salvinorins, salvinorin A (SalA) and salvinorin B (SalB), in three Salvia divinorum dried leaf products and nine of its “concentrated extract” products circulated in Japan were determined. These ingredients were extracted twice with acetonitrile and decolored with graphite carbon powder. SalA and SalB were confirmed by liquid chromatography–tandem mass spectrometry in product ion scan mode, and quantified by high-performance liquid chromatography with UV detection (for SalA) and by mass spectrometry in single ion monitoring mode (for SalB). The SalA/SalB contents (μg/mg) were in the range of 3.2–5.0/0.10–0.17 in the dried leaf products and 4.1–38.9/0.26–2.42 in the “concentrated extract” products. These findings would be useful for analysis of S. divinorum-related products circulated in the drug market. |
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| Keywords: | Salvia divinorum Salvinorin A Salvinorin B Graphite carbon High-performance liquid chromatography |
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