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| SPME-GC-MS法快速检测尿液中的甲基苯丙胺 | |
| 引用本文： | 李学博,周海梅,李朴,马锦琦,程永学,吕宙,齐孝蕊,莫耀南.SPME-GC-MS法快速检测尿液中的甲基苯丙胺[J].中国法医学杂志,2010,25(4):252-254. |
| 作者姓名： | 李学博 周海梅 李朴 马锦琦 程永学 吕宙 齐孝蕊 莫耀南 |
| 作者单位： | 1. 河南科技大学法医学院,河南,洛阳,471003;沂南县公安局,山东,沂南,276300 2. 河南科技大学法医学院,河南,洛阳,471003 3. 临沂市公安局,山东,临沂,276000 |
| 摘 要： | 目的建立SPME-GC-MS快速检测吸毒人员尿液中的甲基苯丙胺的方法。方法以SPME法提取尿液中的甲基苯丙胺,以1-萘胺作内标,用GC-MS法检测。结果在2～2000ng/mL的范围内呈线性关系(r=0.9985,n=7),甲基苯丙胺的检测限为0.5ng/mL(信噪比3),在低、中、高(200、500、1000ng/mL)浓度的平均相对回收率为102.6%、98.5%、93.2%,日内及日间RSD分别小于8.1%、7.2%。结论用此方法检测尿液中的甲基苯丙胺,灵敏度高,简单快速,易操作,适用于吸毒人员的快速定性定量检测。 |
| 关 键 词： | 法医毒物分析 固相微萃取 GC-MS 甲基苯丙胺 |
Rapid detection of methamphetamine in urine by SPME-GC-MS |
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| LI Xuebo,ZHOU Haimei,LI Pu,MA Jinqi,CHENG Yongxue,LV Zhou,QI Xiaorui,MO Yaonan.Rapid detection of methamphetamine in urine by SPME-GC-MS[J].Chinese Journal of Forensic Medicine,2010,25(4):252-254. | |
| Authors: | LI Xuebo ZHOU Haimei LI Pu MA Jinqi CHENG Yongxue LV Zhou QI Xiaorui MO Yaonan |
| Institution: | 1.Faculty of Forensic Medicine,Henan University of Science and Technology,Henan Luoyang 471003,China;2.Yinan Public Security Bureau,Shandong Yinan,Shandong 276300,China;3.Linyi Public Security Bureau,Shandong 276000,China |
| Abstract: | Objective To establish a rapid determination method of methamphetamine in urine of druggers by SPME-GC-MS.Methods The methamphetamine in urine was extracted by SPME and detected using GC-MS with 1-Naphthylamine as internal standard.Results The standard curve was linear in the range of 2～2000ng/mL(r=0.9985,n=7),and the detection limit of methamphetamine was 0.5ng/mL(signal to noise ratio>3),and the average relative recoveries were 102.6%,98.5%,93.2% in low,medium,high concentrations(200,500,1000 ng /mL) respectively,The precisions(RSD) of intra-day and intre-day were less than 8.1% and 7.2%.Conclusion The detection method is high sensitivity,simple and rapid,and it is easy-to-use and suitable for qualitative and quantitative in the fast determination of drug addicts. |
| Keywords: | GC-MS |
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