加味酸枣仁汤联合经颅微电流刺激治疗肝郁血虚型失眠症临床研究

目的观察加味酸枣仁汤联合经颅微电流刺激治疗肝郁血虚型失眠症的临床疗效。方法将52例肝郁血虚型失眠症患者随机分为联合治疗组和西药对照组,每组26例。联合治疗组患者口服加味酸枣仁汤,并接受经颅微电流刺激疗法,西药对照组患者口服艾司唑仑,两组疗程均为4周。治疗前后,分别采用匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)和睡眠状况自评量表(self rating scale of sleep,SRSS)评价患者的睡眠质量;治疗后观察两组的临床疗效、中医证候疗效及安全性。结果联合治疗组与西药对照组治疗后PSQI总分、SRSS总分均较治疗前显著降低(P0.05);两组治疗前后PSQI和SRSS下降程度比较,差异无统计学意义(P0.05);两组临床疗效比较,差异无统计学意义(P0.05);两组中医证候疗效比较,差异具有统计学意义(P0.05);联合治疗组的不良反应比西药对照组少,且随访无反跳。结论加味酸枣仁汤口服联合经颅微电流刺激疗法在改善失眠症状方面与艾司唑仑相似,但在改善肝郁血虚证候方面明显优于艾司唑仑,其不良反应较少,远期疗效较好。

A Clinical Study of Jiawei Suanzaoren Decoction Combined with Transcranial Micro-current Stimulation for Insomnia of Liver Depression and Blood Deficiency

Objective To investigate the clinical efficacy of Jiawei Suanzaoren Decoction combined with transcranial micro-current stimulation in the treatment of insomnia of liver depression and blood deficiency. Methods Fifty-two patients with insomnia of liver depression and blood deficiency were randomly and equally divided into combination treatment group and Western medicine control group. Patients in the combination treatment group were given Jiawei Suanzaoren Decoction by oral administration and transcranial micro-current stimulation for 4 weeks, while patients in the Western medicine control group were given estazolam by oral administration for 4 weeks. The sleep quality in all patients before and after treatment was evaluated using the Pittsburgh sleep quality index (PSQI) and self-rating scale for sleep (SRSS). The clinical outcomes, traditional Chinese medicine (TCM) syndrome outcomes, and safety in both groups were evaluated after treatment. Results The PSQI and SRSS scores in both groups were significantly reduced after treatment (P<0.05). There were no significant differences in the reduction in PSQI and SRSS scores between the two groups after treatment (P>0.05). There were also no significant differences in clinical outcomes between the two groups (P>0.05). There were significant differences in TCM syndrome outcomes between the two groups (P<0.05). The combination treatment group had fewer adverse reactions than the Western medicine control group and had no recurrence during follow-up. Conclusion Compared with estazolam, Jiawei Suanzaoren Decoction combined with transcranial micro-current stimulation achieves similar clinical outcomes in the improvement in insomnia, but better clinical outcomes in the improvement in liver depression and blood deficiency, and this therapy has fewer adverse reactions and achieves better long-term outcomes.