降黄散熏蒸治疗湿热内蕴型新生儿黄疸55例

目的 观察降黄散熏蒸治疗湿热内蕴型新生儿黄疸的临床疗效及安全性。方法 将110例黄疸新生儿按区组随机法分为治疗组和对照组，每组55例。两组患儿均接受蓝光照射，治疗组加用降黄散熏蒸治疗，对照组加用茵栀黄颗粒口服，均治疗5 d，观察两组临床疗效及安全性。结果 两组临床疗效比较，差异无统计学意义（P＞0.05）。治疗后两组患儿血清总胆红素水平均较治疗前明显降低（P＜0.05），两组治疗前后血清总胆红素差值比较，差异无统计学意义（P＞0.05）。治疗组患儿黄疸消退时间较对照组明显缩短（P＜0.05），不良反应发生率明显低于对照组（P＜0.05）。结论 降黄散熏蒸治疗湿热内蕴型新生儿黄疸具有黄疸消退时间短、不良反应少、疗效显著的优势。

Clinical Effect of Fumigation and Steaming Therapy with Jianghuang Powder in Treatment of Neonatal Jaundice with Internal Retention of Damp-heat: an Analysis of 55 Cases

Objective To investigate the clinical effect and safety of fumigation and steaming therapy with Jianghuang Powder in the treatment of neonatal jaundice with internal retention of damp-heat. Methods A total of 110 neonates with jaundice were randomly divided into treatment group and control group, with 55 neonates in each group. All neonates were given blue light irradiation; in addition, the neonates in the treatment group were given fumigation and steaming therapy with Jianghuang Powder, and those in the control group were given oral Yinzhihuang Granule. The course of treatment was 5 days for both groups. The clinical outcome and safety were observed for both groups. Results There was no significant difference in clinical outcome between the two groups (P>0.05). Both groups had a significant reduction in the serum level of total bilirubin after treatment (P<0.05), and there was no significant difference in the degree of reduction between the two groups (P>0.05). Compared with the control group, the treatment group had a significantly shorter time to the disappearance of jaundice and a significantly lower incidence rate of adverse reactions (P<0.05). Conclusion In the treatment of neonatal jaundice with internal retention of damp-heat syndrome, fumigation and steaming therapy with Jianghuang Powder has the advantages of a short time to the disappearance of jaundice, few adverse reactions, and a marked clinical effect.