蓉黄益肾解毒颗粒治疗非透析慢性肾衰竭肾虚湿热证临床观察

目的 观察蓉黄益肾解毒颗粒对非透析慢性肾衰竭（chronic renal failure, CRF）肾虚湿热证患者的临床疗效。方法 选择64例非透析CRF肾虚湿热证患者，随机分为对照组和治疗组各32例。治疗组与对照组均给予中药保留灌肠及西医基础治疗，治疗组加用蓉黄益肾解毒颗粒，每日3次，每次1袋，疗程均为8周。观察两组临床疗效及治疗前后血清肌酐（serum creatinine, SCr）、血尿素氮（blood urea nitrogen, BUN）、胱抑素C（cystatin C, CysC）、同型半胱氨酸（homocysteine, Hcy）水平变化情况。结果 治疗组临床疗效和中医证候疗效均优于对照组（P＜0.05）。治疗前治疗组和对照组SCr、BUN、CysC、Hcy水平比较，差异无统计学意义（P＞0.05）；治疗组治疗后SCr、BUN、CysC、Hcy水平均较治疗前显著降低（P＜0.05），对照组治疗后上述指标无明显变化（P＞0.05）；治疗组治疗前后SCr、BUN、CysC、Hcy差值显著大于对照组（P＜0.05）。结论 蓉黄益肾解毒颗粒能明显改善非透析CRF肾虚湿热证患者的临床症状，保护其肾功能。

Clinical Effect of Ronghuang Yishen Jiedu Granule in Treatment of Non- dialysis Chronic Renal Failure with Kidney- deficiency and Damp- heat Syndrome

Objective To investigate the clinical effect of Ronghuang Yishen Jiedu Granule in the treatment of non- dialysis chronic renal failure (CRF) with kidney- deficiency and damp- heat syndrome. Methods A total of 64 non- dialysis CRF patients with kidney- deficiency and damp- heat syndrome were randomly divided into control group and treatment group, with 32 patients in each group. Both groups were given traditional Chinese medicine (TCM) retention enema and basic Western medicine treatment, and the patients in the treatment group were given Ronghuang Yishen Jiedu Granule (1 bag/time, three times a day) in addition. The course of treatment was 8 weeks for both groups. The clinical outcome and changes in serum creatinine (SCr), blood urea nitrogen (BUN), cystatin C (CysC), and homocysteine (Hcy) were observed after treatment. Results The treatment group had significantly better clinical outcome and TCM syndrome outcome than the control group (P<0.05). There were no significant differences in the levels of SCr, BUN, CysC, and Hcy before treatment between the two groups (P>0.05). After treatment, the treatment group had significant reductions in the levels of SCr, BUN, CysC, and Hcy (P<0.05), while the control group showed no significant changes (P>0.05). The treatment group had significantly greater changes in the levels of SCr, BUN, CysC, and Hcy after treatment than the control group (P<0.05). Conclusion Ronghuang Yishen Jiedu Granule can significantly alleviate clinical symptoms and protect renal function in non- dialysis CRF patients with kidney- deficiency and damp- heat syndrome.