肾康注射液联合还原型谷胱甘肽治疗慢性肾脏病疗效观察

目的 观察肾康注射液联合还原型谷胱甘肽治疗慢性肾脏病（chronic kidney disease，CKD）的疗效。方法 将70例CKD患者随机分为对照组（34例）及治疗组（36例）。治疗组主要予以常规治疗，对照组在治疗组基础上加用肾康注射液联合还原型谷胱甘肽静脉滴注，疗程均为4周。观察两组临床疗效以及治疗前后血尿素氮（blood urea nitrogen, BUN）、血清肌酐（serum creatinine, SCr）、估算的肾小球滤过率（estimated glomerular filtration rate， eGFR）、胱抑素C（cystatin C, Cys-C）水平。结果 两组临床疗效的分布比较，差异具有统计学意义（P＜0.05），治疗组的临床疗效优于对照组。治疗组治疗后BUN、SCr、Cys-C水平较治疗前明显下降（P＜0.05），eGFR水平明显升高（P＜0.05）；治疗组治疗前后BUN、SCr、Cys-C、eGFR差值与对照组比较，差异均有统计学意义（P＜0.05）。结论 肾康注射液联合还原型谷胱甘肽治疗慢性肾脏病疗效显著。

Clinical Effect of Shenkang Injection Combined with Reduced Glutathione in Treatment of Chronic Kidney Disease

Objective To investigate the clinical effect of Shenkang injection combined with reduced glutathione in the treatment of chronic kidney disease (CKD). Methods A total of 70 CKD patients were randomly divided into control group with 34 patients and treatment group with 36 patients. The patients in the control group were given conventional treatment, and those in the treatment group were given intravenous drip of Shenkang injection combined with reduced glutathione in addition to the conventional treatment. The course of treatment was 4 weeks for both groups. The clinical outcome was observed for the two groups, as well as blood urea nitrogen (BUN), serum creatinine (SCr), estimated glomerular filtration rate (eGFR), and cystatin C (Cys-C) before and after treatment. Results There was a significant difference in the distribution of clinical outcomes between the two groups (P<0.05), and the treatment group had a significantly better clinical outcome than the control group (P<0.05). The treatment group had significant reductions in the levels of BUN, SCr, and Cys-C and a significant increase in eGFR after treatment (P<0.05); there were significant differences in BUN, SCr, Cys-C, and eGFR between the two groups before and after treatment (P<0.05). Conclusion Shenkang injection combined with reduced glutathione has a good clinical effect in the treatment of CKD.