溃疡性结肠炎大肠湿热证与凝血功能相关性研究

目的 探讨溃疡性结肠炎（ulcerative colitis，UC）大肠湿热证候积分与凝血功能的相关性。方法 收集86例大肠湿热型UC患者，检测其血小板（platelet，PLT）计数、平均血小板体积（mean platelet volume，MPV、纤维蛋白原（fibrinogen，Fib）、凝血酶原时间（prothrombin time，PT）和D-二聚体（D-dimer，D-D）水平，比较不同病情UC患者的大肠湿热证积分、Mayo积分和凝血功能，采用Pearson相关分析方法研究大肠湿热证积分与凝血相关指标的相关性。结果 与缓解期比较，活动期UC患者大肠湿热证积分、Mayo积分、PLT、D-D、Fib均显著升高（P＜0.05），MPV和PT均显著下降（P＜0.05）；活动期UC患者，病情程度越重，大肠湿热证积分、Mayo积分、PLT、D-D、Fib越高，MPV和PT越低；轻度、中度、重度病情三者间大肠湿热证积分、Mayo积分、PLT、D-D、Fib、MPV、PT比较，差异均具有统计学意义（P＜0.05）。大肠湿热证积分与Mayo积分、PLT、Fib、D-D呈正相关（P＜0.05），与PT、MPV呈负相关（P＜0.05）。结论 大肠湿热型UC患者存在血液高凝状态，是清热除湿法改善凝血功能的临床依据。

Association between Large Intestine Damp-heat Syndrome and Coagulation Function in Patients with Ulcerative Colitis

Objective To investigate the association between large intestine damp-heat syndrome score and coagulation function in patients with ulcerative colitis (UC). Methods A total of 86 UC patients with large intestine damp-heat syndrome were enrolled, and the platelet count (PLT), mean platelet volume (MPV), fibrinogen (Fib) level, prothrombin time (PT), and D-dimer (D-D) level were measured. The large intestine damp-heat syndrome score, Mayo score, and coagulation function were compared between patients with different conditions. Pearson correlation analysis was used to investigate the correlation between large intestine damp-heat syndrome score and coagulation markers. Results Compared with those in the remission stage, the UC patients in the active stage had significant increases in the large intestine damp-heat syndrome score, Mayo score, PLT, D-D level, and Fib level (P<0.05) and significant reductions in MPV and PT (P<0.05). In the UC patients in the active stage, with the aggravation of UC, the large intestine damp-heat syndrome score, Mayo score, PLT, D-D level, and Fib level increased and the MPV and PT decreased. There were significant differences in large intestine damp-heat syndrome score, Mayo score, PLT, D-D level, Fib level, MPV, and PT between mild, moderate, and severe cases (P<0.05). The large intestine damp-heat syndrome score was positively correlated with the Mayo score, PLT, Fib level, and D-D level (P<0.05) and negatively correlated with PT and MPV (P<0.05). Conclusion UC patients with large intestine damp-heat syndrome have hypercoagulability, which is the clinical basis for improving coagulation function by clearing heat and removing dampness.