清热利湿法联合西药治疗湿热型类风湿关节炎临床观察

目的 观察口服清热利湿中药联合西药治疗湿热型类风湿关节炎（rheumatoid arthritis，RA）的临床疗效。方法 采用随机数字表法将62例患者按就诊顺序随机分为治疗组和对照组，每组31例。对照组患者口服来氟米特、美洛昔康；治疗组加服复方芪薏胶囊和黄芩清热除痹胶囊，12周后观察疗效。结果 治疗组总有效率显著高于对照组（80.665% vs 64.52%, P<0.05），降低血清C 反应蛋白和类风湿因子水平，以及降低健康状况评分、抑郁自评量表评分和焦虚自评量表评分方面，治疗组显著优于对照组（P<0.01）。结论 口服清热利湿中药联合西药治疗湿热型RA临床疗效确切，能够改善患者的精神心理状态，提高患者的适应社会能力。

Clinical Efficacy of Heat clearing and Diuresis promoting Prescription Combined with Western Medicine Treatment for Damp heat Rheumatoid Arthritis

Objective To observe the clinical efficacy of oral heat- clearing and diuresis- promoting traditional Chinese medicines (TCMs) combined with Western medicine treatment for damp- heat rheumatoid arthritis (RA). Methods Sixty- two patients with damp- heat RA were randomly divided into treatment group (n=31) and control group (n=31) according to the visiting order. The control group received oral leflunomide and meloxicam; the treatment group received compound Qiyi Capsule and Huangqin heat- clearing and arthralgia- removing Capsule in addition to the therapy for the control group. The treatment outcomes of the two groups were evaluated after 12 weeks of treatment. Results The treatment group had a significantly higher overall response rate than the control group (80.665% vs 64.52%, P<0.05). Moreover, the treatment group had significantly higher decreases in serum levels of C- reactive protein and rheumatoid factors and scores on Health Scale, Self- Rating Depression Scale, and Self- Rating Anxiety Scale than the control group (P<0.01). Conclusion Oral heat- clearing and diuresis- promoting TCMs combined with Western medicine treatment have good clinical efficacy in treating damp- heat RA and can improve the mental status and social adaptability of patients.