“清肺散”穴位贴敷治疗痰热郁肺证慢性阻塞性肺疾病急性加重35例

目的观察"清肺散"穴位贴敷对痰热郁肺证慢性阻塞性肺疾病急性加重(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的临床疗效。方法将痰热郁肺证AECOPD患者70例采用随机数字表法分为观察组和对照组,每组35例。对照组予西医常规治疗,观察组在对照组基础上予以"清肺散"穴位贴敷治疗,疗程为10d。比较两组患者的临床疗效、治疗前后动脉血氧分压(partial pressure of oxygen,PaO2)和动脉血二氧化碳分压(partial pressure of carbon dioxide,PaCO2)以及血清降钙素原(procalcitonin,PCT)和超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平的变化情况。结果两组临床疗效分布比较,差异有统计学意义(P<0.05),观察组疗效优于对照组;治疗后,两组患者的PaO2水平较治疗前显著升高,PaCO2水平较治疗前显著降低,差异均有统计学意义(P<0.05);两组治疗前后PaO2、PaCO2差值比较,差异均有统计学意义(P<0.05);治疗后,两组PCT、hs-CRP水平较治疗前降低,差异均有统计学意义(P<0.05),两组治疗前后PCT、hs-CRP差值比较,差异均具有统计学意义(P<0.05)。结论 "清肺散"穴位贴敷联合西医常规治疗可以改善AECOPD患者缺氧状态,减轻炎症程度,提高临床疗效。

Clinical Effect of Acupoint Application with Qingfei Powder in Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Phlegm-Heat Obstructing the Lungs: An Analysis of 35 Cases

Objective To investigate clinical effect of acupoint application with Qingfei Powder in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with phlegm-heat obstructing the lungs. Methods A total of 70 patients with AECOPD with phlegm-heat obstructing the lungs were divided into observation group and control group using a random number table, with 35 patients in each group. The patients in the control group were given conventional Western medicine treatment, and those in the observation group were given acupoint application with Qingfei Powder in addition to the treatment in the control group. The course of treatment was 10 days for both groups. The two groups were compared in terms of clinical outcome and changes in partial pressure of oxygen (PaO2), partial pressure of carbon dioxide (PaCO2) in artery, procalcitonin (PCT), and high-sensitivity C-reactive protein (hs-CRP) after treatment. Results There was a significant difference in the distribution of clinical outcomes between the two groups (P<0.05), and the observation group had a better clinical outcome than the control group. After treatment, both groups had a significant increase in PaO2 and a significant reduction in PaCO2 (P<0.05), and there were significant differences in such changes between the two groups (P<0.05). After treatment, both groups had significant reductions in PCT and hs-CRP (P<0.05), and there were significant differences in such changes between the two groups (P<0.05). Conclusion Acupoint application with Qingfei Powder combined with conventional Western medicine treatment can improve hypoxia, alleviate the degree of inflammation, and improve clinical outcome in patients with AECOPD.