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| 洛非西定对大鼠吗啡药代动力学的影响研究 | |
| 引用本文： | 王玉瑾,张加玲,贠克明,田树华,王英元. 洛非西定对大鼠吗啡药代动力学的影响研究[J]. 中国法医学杂志, 2000, 15(4): 217-219 |
| 作者姓名： | 王玉瑾 张加玲 贠克明 田树华 王英元 |
| 作者单位： | 1. 山西医科大学法医学系,太原,030001 2. 山西医科大学公共卫生学院,太原,030001 3. 山西医科大学医学实验中心,太原,030001 |
| 基金项目： | 山西省自然科学基金资助!(基金编号 9710 5 2 ) |
| 摘 要： | 用放射免疫测定方法 ,研究大鼠皮下注射盐酸吗啡及盐酸吗啡合并灌服盐酸洛非西定后 ,大鼠吗啡的药代动力学。结果表明 ,在合并用洛非西定后 ,大鼠血清吗啡的T1/2Ka由 0 2 5 7h增加到 0 349h ,T1/2K由 2 5 0 2h减少到 2 2 5 0h ,Cmax由 3330 μg·L-1减少到 16 48μg·L-1,AUC由 12 390h·μg·L-1减少到 72 80 6h·μg·L-1,CL由 0 80 7L·h-1·kg-1增加到 1 374L·h-1·kg-1。洛非西定可降低吗啡的吸收及血液中吗啡的浓度 ,加快吗啡在大鼠体内的总体清除率 |
| 关 键 词： | 吗啡 洛非西定 药代动力学 放射免疫法 |
| 修稿时间： | 2000-03-01 |
Effects of lofexidine on the pharmacokinetics of morphine in rats |
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| WANG Yujin. Effects of lofexidine on the pharmacokinetics of morphine in rats[J]. Chinese Journal of Forensic Medicine, 2000, 15(4): 217-219 | |
| Authors: | WANG Yujin |
| Abstract: | The pharmacokinetics of morphine in rats was studied after treatment with morphine, as well as morphine and lofexidine. The results showed that in lofexidine group the T 1/2ka and CL of morphine was significantly increased, while the C max ,AUC and T 1/2k of morphine were significantly decreased. Our results indicate that the lofcxidine can reduce the absorption rate of the morphine and the concentration of morphine in blood, and then can increase the total clearance rate of morphine in rats. |
| Keywords: | Morphine Lofexidine Pharmacokinetics RadioimmunoassayL |
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