| X染色体遗传标记研究进展 |
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| 作者姓名： | Zhang WJ Zhou XP Jia ZJ |
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| 作者单位： | 四川大学华西基础医学与法医学院,四川,成都,610041 |
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| 摘 要： | 随着人类基因组计划的进展,全面深入地了解个体和群体间基因组的变异或多态性已成为可能,并日益显示其重要性。X染色体遗传标记的遗传多态性较多地表现在短串联重复序列和单核苷酸的多态性。这类多态性有助于解释个体的表型差异、不同群体和个体对疾病,特别是对复杂疾病的易感性、以及对各种药物的耐受性和对环境因子的反应,因此受到临床及法医工作者的重视。本文收集了国内外X染色体遗传标记在临床疾病诊断及法医DNA工作者实践中的研究和应用资料,汇总报道了X染色体遗传标记的研究进展。
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| 关 键 词： | X染色体 短串联重复序列 单核苷酸多态性 |
| 文章编号： | 1004-5619(2003)04-0249-04 |
| 修稿时间： | 2003年4月22日 |
Proceeding of research on X chromosome genetic markers |
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| Zhang WJ,Zhou XP,Jia ZJ.Proceeding of research on X chromosome genetic markers[J].Journal of Forensic Medicine,2003,19(4):249-252. |
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| Authors: | Zhang Wei-juan Zhou Xue-ping Jia Zhen-jun |
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| Institution: | West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. |
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| Abstract: | The development of Human Genome Project(HGP)makes it possible and more important to reveal the variations or polymorphisms precisely between different individuals and populations.Due to the characters of their high polymorphism and value in disease-linkage analysis as well as pharmacogenomnics,genetic markers on X chromosome have attracted much more attention of current medical and forensic scientists.This report summarized the proceeding of research on X chromosome genetic markers in the clinical and forensic context. |
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| Keywords: | X chromosome RFLP Polymorphism STR SNP |
| 本文献已被 CNKI 维普 万方数据 PubMed 等数据库收录！ |
