| 中国北方汉族群体TPH基因座T3792A位点遗传多态性 |
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| 引用本文： | 王兵,王保捷,丁梅,庞灏,张振,关红玉,吕洪涛.中国北方汉族群体TPH基因座T3792A位点遗传多态性[J].法医学杂志,2008,24(6):437-438. |
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| 作者姓名： | 王兵 王保捷 丁梅 庞灏 张振 关红玉 吕洪涛 |
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| 作者单位： | 中国医科大学法医学院,中国沈阳,110001 |
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| 基金项目： | 辽宁省教育厅资助项目
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| 摘 要： | 目的研究中国北方汉族群体色胺酸羟化酶（TPH）基因座T3792A位点的遗传多态性及其法医学应用价值。方法应用等位基因特异性PCR的方法，检测173例中国北方汉族无关个体TPH基因座T3792A位点的遗传多态性。结果TPH基因座T3792A位点在中国北方汉族群体中的多态性分布符合Hardy—Weinberg平衡定律，等位基因A及T的频率分别为0．486和0．514。结论TPH基因座T3792A位点具有较好的遗传多态性．可应用于个体识别与亲权鉴定。
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| 关 键 词： | 法医遗传学 多态性 单核苷酸 色胺酸羟化酶 北方汉族群体 |
Polymorphism of TPH Gene T3792A Locus in Han Ethnic Group of North China |
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| WANG Bing,WANG Bao-jie,DING Mei,PANG Hao,ZHANG Zhen,GUAN Hong-yu,LU Hong-tao.Polymorphism of TPH Gene T3792A Locus in Han Ethnic Group of North China[J].Journal of Forensic Medicine,2008,24(6):437-438. |
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| Authors: | WANG Bing WANG Bao-jie DING Mei PANG Hao ZHANG Zhen GUAN Hong-yu LU Hong-tao |
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| Institution: | WANG Bing, WANG Bao-jie, DING Mei, PANG Hao, ZHANG Zhen, GUAN Hong-yu, LU Hong-tao (School of Forensic Medicine, China Medical University, Shenyang 110001, China) |
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| Abstract: | Objective To investigate the polymorphism of the TPH gene T3792A locus in Han ethnic group of north China and its application value in forensic science. Methods The polymorphism of T3792A locus of the TPH gene was analyzed by the ASPCR of blood samples from 173 unrelated individuals of north Chinese Han population. Results The distribution of the T3792A locus polymorphism of the TPH gene in Han ethnic group of north China followed the Hardy-Weinberg law, with the allele A and T gene frequency of 0.486 and 0.514, respectively. Conclusion The TPH gene T3792A locus shows a very good genetic polymorphism, and may be applied to individual identification and paternity testing. |
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| Keywords: | forensic genetics polymorphism single nucleotide tryptophan hydroxylase han ethnic group of north China |
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