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| 海洛因成瘾者神经、内分泌及免疫系统超微病理变化研究 | |
| 引用本文： | Li LH,Yao H,Zhao YH,Zhu H,Xing YM,Feng ZT,Yang RX. 海洛因成瘾者神经、内分泌及免疫系统超微病理变化研究[J]. 法医学杂志, 2001, 17(3): 145-147 |
| 作者姓名： | Li LH Yao H Zhao YH Zhu H Xing YM Feng ZT Yang RX |
| 作者单位： | 1. 昆明医学院法医学系, 2. 云南省公安厅技术处, 3. 昆明医学院神经科学研究所, 4. 云南省肿瘤医院综合内科, |
| 基金项目： | 国家自然科学基金资助项目（ No.39760076） |
| 摘 要： | 目的 研究海洛因成瘾者中枢神经、内分泌、免疫及生殖系统的超微结构变化。方法 应用透射电镜技术对 4例海洛因成瘾者中枢神经系统、内分泌系统、免疫系统以及生殖系统进行了观察。结果 神经系统表现为线粒体肿胀、嵴断裂、空泡变、内质网扩张、神经纤维数量减少、细胞器减少;免疫系统表现为淋巴细胞数量减少,胞浆成分减少,死亡细胞增多;内分泌系统表现为线粒体扩张,局部嵴断裂,内质网扩张;生殖系统表现为男性生精细胞减少,细胞器减少。女性未见卵泡结构。结论 海洛因滥用者的亚细胞超微结构呈急、慢性缺氧性变性、坏死改变。 |
| 关 键 词： | 海洛因成瘾者 中枢神经系统 内分泌系统 免疫系统 生殖系统 超微病理变化 透射电镜技术 |
| 文章编号： | 1004－ 5619(2001)03－ 0145－ 03 |
| 修稿时间： | 2001-04-30 |
Research of ultra-structural pathological changes of nervous,endocrine and immune system in heroin addicts |
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| Li L H,Yao H,Zhao Y H,Zhu H,Xing Y M,Feng Z T,Yang R X. Research of ultra-structural pathological changes of nervous,endocrine and immune system in heroin addicts[J]. Journal of Forensic Medicine, 2001, 17(3): 145-147 | |
| Authors: | Li L H Yao H Zhao Y H Zhu H Xing Y M Feng Z T Yang R X |
| Affiliation: | Department of Forensic Medicine, Kunming Medical College, Kunming 650031. |
| Abstract: | OBJECTIVE: To investigate ultrastructural pathological changes of Heroin-Addicts. METHODS: Heroin-Addicts' central nervous system, endocrine system, immune system and reproductive system in 4 cases are observed by using transmission electron microscope(TEM). RESULTS: The changes of central nervous system are mitochondrion swelling, crista fragmentation and disappear. Endoplasmic reticulum dilation, nervous fibres and cell organelles reduction; mitochondrion swelling, Partial crista fragmentation and endoplasmic reticulum dilation are also found in endocrine system; Lymphocytes reduction, cytoplasm ingredient reduction and dead lymphocytes increase in immune system; in reproductive system, spermatogenic cells and cell organelles are reduced in the male and follicle disappeared in the female. CONCLUSION: Ultra-structural pathological changes of heroin-addicts are presented acute, chronic oxygen deficiency degeneration and necrosis. |
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