Determination of succinyldicholine in different tissue samples from guinea pigs after injection of a single intravenous dose |
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| Authors: | D Malthe-S?renssen E Odden J Blanch A Bugge J M?rland |
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| Affiliation: | 1. Norwegian Defence Research Establishment, Division for Environmental Toxicology, P.O. Box 25, N-2007 Kjeller Norway;2. National Institute of Forensic Toxicology, Sognsvannsveien 28 0372 Oslo 3, Norway;1. Department of Radiology, Icahn School of Medicine at Mount Sinai, United States;2. Department of Radiology, NYU Langone Health, United States;3. Department of Medicine, Icahn School of Medicine at Mount Sinai, United States;4. Department of Radiology, Columbia University Medical Center, United States;1. Department of Legal Medicine, Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan;2. Forensic Autopsy Section, Medico-legal Consultation and Postmortem Investigation Support Center, c/o Osaka City University Medical School, Asahi-machi 1-4-3, Abeno, Osaka 545-8585, Japan;3. Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Minia University, Minia 61111, Egypt;4. Division of Legal Medicine, Faculty of Medicine, Tottori University, Nishi-cho 86, Yonago, Tottori 683-8503, Japan |
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| Abstract: | The distribution and postmortem stability of succinyldicholine in different tissues and urine from guinea-pigs has been studied. Succinyldicholine was extracted from tissue homogenates and urine samples from animals sacrificed by intravenous injections of succinyldicholine hydrochloride (40 mg/kg). The bis-quaternary ammonium compound was demethylated and the tertiary amine was analysed by gas chromatography/mass spectrometry. The concentrations found in muscle, kidney and urine were often low; in muscle below 5 pmol/g, in kidney from 5 to 1500 pmol/g and in urine from 5 to 650 pmol/ml. The eye proved to be the best tissue sample, with a rather high and constant concentration (280 +/- 36 pmol/g) of succinyldicholine. The postmortem stability was studied by storing the bodies at 4 degrees C. After 6 days storage the drug concentrations in the eyes started to decline. Four weeks after death it was not possible to detect any succinyldicholine in this tissue. |
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